Structure of PDB 6o3p Chain B Binding Site BS04

Receptor Information
>6o3p Chain B (length=320) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMLDRRSDKRNNSDWLQAKESHPTTVYLLFSDLNPLVTLGGNKESSQQPE
VRLCQLNYPDVKGYLAQPEKITLVFLGVELEMRKAADGLVAWFALGIEPG
AAEEFKQRHENCYFLHPPMPALLQLKEKEAGVVAQARSVLAWHSRYKFCP
TCGSATKIEEGGYKRVCVRETCPSLQGVHNTSYPRVDPVVIMQVIHPDGT
KCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVKVGHVQYV
SCQPWPMPSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTAFF
VPPSRAIAHQLIKHWVGMNP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6o3p Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6o3p Structural and mechanistic basis of mammalian Nudt12 RNA deNADding.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		A354 E374 E415
Binding residue
(residue number reindexed from 1)		A219 E239 E280
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.-
3.6.1.22: NAD(+) diphosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6o3p, PDBe:6o3p, PDBj:6o3p
PDBsum6o3p
PubMed31101919
UniProtQ9DCN1|NUD12_MOUSE NAD-capped RNA hydrolase NUDT12 (Gene Name=Nudt12)

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