Structure of PDB 6myo Chain B Binding Site BS04

Receptor Information

>6myo Chain B (length=240) Species: 9031 (Gallus gallus)

TSRIKKFSIYRWDPDKPGDKPRMQTYEVDLNKCGPMVLDALIKIKNELDS
TLTFRRSCREGICGSCAMNIAGGNTLACTKKIDPDLSKTTKIYPLPHMYV
VKDLVPDLSNFYAQYKSIEPYLKKKDESKQGKEQYLQSIEDRQKLDGLYE
CILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDYTEERLAQLQ
DPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKE

Ligand information

• Ligand ID: FTN
• InChI: InChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22)
• InChIKey: PTCGDEVVHUXTMP-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.352: CC(C)Oc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
  OpenEye OEToolkits 1.7.0: CC(C)Oc1cccc(c1)NC(=O)c2ccccc2C(F)(F)F
• Formula: C17 H16 F3 N O2
• Name: N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide;
  flutolanil;
  N-(3-Isopropoxy-phenyl)-2-trifluoromethylbenzamide
• ChEMBL: CHEMBL487185
• ZINC: ZINC000000001479
• PDB chain: 6myo Chain C Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6myo Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): W173 H216 I218
• Binding residue (residue number reindexed from 1): W166 H209 I211
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0006099 tricarboxylic acid cycle

External links

• PDB: RCSB:6myo, PDBe:6myo, PDBj:6myo
• PDBsum: 6myo
• PubMed: 34089891
• UniProt: Q9YHT2|SDHB_CHICK Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Gene Name=SDHB)