Structure of PDB 6mlc Chain B Binding Site BS04

Receptor Information
>6mlc Chain B (length=85) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQC
RQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6mlc Chain B Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6mlc Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C1103 C1106 C1133 C1136
Binding residue
(residue number reindexed from 1)		C50 C53 C80 C83
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:6mlc, PDBe:6mlc, PDBj:6mlc
PDBsum6mlc
PubMed30604749
UniProtQ8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

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