Structure of PDB 6fwk Chain B Binding Site BS04

Receptor Information
>6fwk Chain B (length=1099) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWL
TNMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRV
NDVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQL
FEARKLLRPILQDNANNNVQRNIYNVVDAKHLIEDIREYDVPYHVRVSID
KDIRVGKWYKVTQQGFIEDTRKIAFADPVVMAFDIETTKPPLKFPDSAVD
QIMMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEV
ALLQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAP
DAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDP
ELMTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDE
TLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGG
HVESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDK
VTNFEEIKNQITQKLLELKENNIRNELPLIYHVDVASGYPNIMTTNRLQP
DSIKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNLTFDELSYAD
QVIHIKKRLTEYSRKVSEIVEREAIVCQRENPFYVDTVKSFRDRRYEFKG
LAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAHKVILNSFYGYVMR
KGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKS
FPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYET
HSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFNEDGSLAELKGFEL
KRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVCNRWLDVLDSHGLM
LEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRLGDFLGEDMVKDKG
LQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFLRRWTLDPSLEDLD
IRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHPDWLKRKIA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6fwk Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 V554 G555 G556 V558 R686 S829 G832 M835 R836 K837 I965 K966 K967 R968 R988 K1063 V1102 T1103 Y1145 K1156
Binding residue
(residue number reindexed from 1)		K454 G455 T456 G457 T458 T496 Y497 V498 G499 G500 V502 R615 S743 G746 M749 R750 K751 I879 K880 K881 R882 R902 K977 V1016 T1017 Y1059 K1070
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fwk, PDBe:6fwk, PDBj:6fwk
PDBsum6fwk
PubMed30670696
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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