Structure of PDB 5xen Chain B Binding Site BS04

Receptor Information

>5xen Chain B (length=301) Species: 190304 (Fusobacterium nucleatum subsp. nucleatum ATCC 25586)

LANSVIDLIGNTPLVKINNIDTFGNEIYVKLEGSNPGRSTKDRIALKMIE
EAEKEGLIDKDTVIIEATSGNTGIGLAMICAVKNYKLKIVMPDTMSIERI
QLMRAYGTEVILTDGSLGMKACLEKLEELKKNEKKYFVPNQFTNVNNPKA
HYETTAEEILKDLNNKVDVFICGTGTGGSFSGTAKKLKEKLPNIKTFPVE
PASSPLLSKGYIGPHKIQGMGMSIGGIPAVYDGSLADDILVCEDDDAFEM
MRELSFKEGILGGISTGATFKAALDYSKENADKGLKIVVLSTDSGEKYLS
N

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5xen Chain B Residue 405

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5xen Purification, crystallization and preliminary X-ray analysis of two hydrogen sulfide-producing enzymes from Fusobacterium nucleatum.
• Resolution: 1.94 Å
• Binding residue (original residue number in PDB): E244 D246
• Binding residue (residue number reindexed from 1): E243 D245
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding
• GO:0080146 L-cysteine desulfhydrase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0006535 cysteine biosynthetic process from serine
• GO:0009069 serine family amino acid metabolic process
• GO:0044272 sulfur compound biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5xen, PDBe:5xen, PDBj:5xen
• PDBsum: 5xen
• UniProt: Q8RE94