Structure of PDB 5wfc Chain B Binding Site BS04

Receptor Information
>5wfc Chain B (length=769) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWTVDKIASALSVLAEEVPQNHSRLVNFLLEETEKRAPQPRHLSKTDPFA
HMKSKAIDGVPTMDVKFKQHSGEYGKSRNSGRRFQYPVVCIKPDREPVPI
YYFHHAEIRKNILALNSQLNPRSQKIAKRAQAEYAATLAPYLEPWLRKLN
IEGCTKSNLIRFMASQPESDDSMTPQQKSNLLDTYSDDMGSPQAVRNASM
FTEAWDRVFNDQSKLRRVALRDILMLDKNVEPIFDNKRAKLMQKVIDALG
SYTTLGCLICFSHDCEHGEIERDNQKRCFSLEEIGGLMPSLRRKWAAQIE
QHPPCRNECYRIHGVPPWSENEVGTLEWMFATIGYSQTLRPECFVGAILG
RPCWDVHRKLQEIPKQKSLPWYDRRKKQLMSDWADATITHEHAVRELFAP
CHHDGPCTAANGCPCASAGTHPVLCERFCLCTAEECPLKFTGCACHSSGK
TCLQRQGRPCICVQLNRECDPTLCKGCGARERADPENAYDEVLHSTGCQN
VALQRGAAKAVVLGKSQLEACGYGLFAAEDIEEGEFVIEYTGELISHDEG
VRREHRRGSFLFTLLEQEGIWVDAAIYGNLSRYINHATDGNIMPKIMYVN
HEWRIKFTAIKDIKAGEELFFNYGDNFPNLTKKLPLLVPKTTQPLFDPLS
KVQLLPGQPLPQHPIDDSWLLLKHRDNLQDFIDLRPEEKEFLQEWDAFIL
RRHISSEQYLPRYFLRFVREKADWLVSKRSRGEEFSKLVATLLARRVLPE
RVVIEATQVLNDARGRLRE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5wfc Chain B Residue 8004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wfc An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.
Resolution2.282 Å
Binding residue
(original residue number in PDB)		C685 H687 C691 C697
Binding residue
(residue number reindexed from 1)		C401 H403 C407 C413
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Biological Process
GO:0006338 chromatin remodeling

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Molecular Function
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Biological Process
External links
PDB RCSB:5wfc, PDBe:5wfc, PDBj:5wfc
PDBsum5wfc
PubMed29904056
UniProtG0RYC6;
G0SDW4

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