Structure of PDB 5uan Chain B Binding Site BS04

Receptor Information
>5uan Chain B (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVT
RNRCQYCRLQKCFEVGMSKESVRTAELDDLTEKIRKAHQETFPSLCQLGK
YTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQ
ITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLE
ALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMP
PLIQEMLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5uan Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5uan The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission.
Resolution3.508 Å
Binding residue
(original residue number in PDB)		C81 C101
Binding residue
(residue number reindexed from 1)		C2 C22
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uan, PDBe:5uan, PDBj:5uan
PDBsum5uan
PubMed29021580
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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