Structure of PDB 5u6n Chain B Binding Site BS04

Receptor Information
>5u6n Chain B (length=448) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEHKRGHVLAVPYPSQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINP
DLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQT
SDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNG
SLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVN
SFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKD
DSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRS
SEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTME
ALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEF
SIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS
Ligand information
Ligand IDUDP
InChIInChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyXCCTYIAWTASOJW-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.370O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
CACTVS 3.370O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.0C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O
FormulaC9 H14 N2 O12 P2
NameURIDINE-5'-DIPHOSPHATE
ChEMBLCHEMBL130266
DrugBankDB03435
ZINCZINC000004490939
PDB chain5u6n Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5u6n Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana.
Resolution2.001 Å
Binding residue
(original residue number in PDB)		G272 S273 V297 W324 S325 Q327 H342 G344 N346 S347 E350
Binding residue
(residue number reindexed from 1)		G272 S273 V297 W324 S325 Q327 H342 G344 N346 S347 E350
Annotation score3
Enzymatic activity
Enzyme Commision number 2.4.1.-
Gene Ontology
Molecular Function
GO:0008194 UDP-glycosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0035251 UDP-glucosyltransferase activity
GO:0052639 salicylic acid glucosyltransferase (ester-forming) activity
GO:0052640 salicylic acid glucosyltransferase (glucoside-forming) activity
GO:0052641 benzoic acid glucosyltransferase activity
GO:0080002 UDP-glucose:4-aminobenzoate acylglucosyltransferase activity
GO:0090704 nicotinate-O-glucosyltransferase activity
Biological Process
GO:0009696 salicylic acid metabolic process
GO:0010030 positive regulation of seed germination
GO:0018874 benzoate metabolic process
GO:0046482 para-aminobenzoic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5u6n, PDBe:5u6n, PDBj:5u6n
PDBsum5u6n
PubMed28425481
UniProtO22822|U74F2_ARATH UDP-glycosyltransferase 74F2 (Gene Name=UGT74F2)

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