Structure of PDB 5jc3 Chain B Binding Site BS04

Receptor Information
>5jc3 Chain B (length=661) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GDLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKA
SEQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEV
VKRYDVIICTAQILENSLLNATEESVRLSDFSLIIIDQCHHTQKEGVYNN
IMRRYLKEKIKNRKQAKELIPQPQILGLTASPGVGGARSNSKAEEHILKI
CANLDACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQ
DIQKYCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYND
ALQINDTIRMVDAYNHLNNFYKELKRRKTAESDDDSKQDETDEFLMRLFH
AKKKQLKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSAL
ALYHWIMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGS
INLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYAL
VASSGSGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIV
EKQMKAKRDQRITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHK
RENYQTNVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDTKEIFK
KWGELPIIFPD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5jc3 Chain B Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5jc3 Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C881 C884 C936 C939
Binding residue
(residue number reindexed from 1)		C566 C569 C612 C615
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5jc3, PDBe:5jc3, PDBj:5jc3
PDBsum5jc3
PubMed27203181
UniProtD9N195

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