Structure of PDB 4zi8 Chain B Binding Site BS04

Receptor Information

>4zi8 Chain B (length=323) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HENLYFQGSTIIHYEILEERERGFPVGNVVTDLGLDLGSLSARRLRVVSG
ASRRFFEVNWETGEMFVNDRLDREELCGTLPSCTVTLELVVENPLELFSA
EVVVQDINDNNPSFPTGEMKLEISEALAPGTRFPLESAHDPDVGSNSLQT
YELSHNEYFALRVQTREDGTKYAELVLERALDWEREPSVQLVLTALDGGT
PARSATLPIRITVLDANDNAPAFNQSLYRARVREDAPPGTRVAQVLATDL
DEGLNGEIVYSFGSHNRAGVRELFALDLVTGVLTIKGRLDFEDTKLHEIY
IQAKDKGANPEGAHCKVLVEVVD

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

4zi8 Chain B Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4zi8 Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.
Resolution	1.698 Å
Binding residue (original residue number in PDB)	E116 E175 D206 A207 D209 D242
Binding residue (residue number reindexed from 1)	E125 E184 D215 A216 D218 D251
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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External links

PDB	RCSB:4zi8, PDBe:4zi8, PDBj:4zi8
PDBsum	4zi8
PubMed	26481813
UniProt	Q91XX1

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