Structure of PDB 4ri9 Chain B Binding Site BS04

Receptor Information
>4ri9 Chain B (length=615) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGHPYYLRSFLVVLKTVLENEDDMLLFDEQEKGIVTKFYQLSATGQKLYV
RLFQRKLSWIKMTKLEYEEIALDLTPVIEELTNAGFLQTESELQELSEVL
ELLSAPELKSLAKTFHLANPNGQKQQLVDAFLKLAKQRSVIGAVILKRAK
ALAGQSVRICKGPRAVFSRILLLFSLTDSMEDEDAACGGQGQLSTVLLVN
LGRMEFPSYTINRKTHIFQDRDDLIRYAAATHMLSDISSAMANGNWEEAK
ELAQCAKRDWNRLKNHPSLRCHEDLPLFLRCFTVGWIYTRILSRFVEILQ
RLHMYEEAVRELESLLSQRIYCPDSRGRWWDRLALNLHQHLKRLEPTIKC
ITEGLADPEVRTGHRLSLYQRAVRLRESPSCKKFKHLFQQLPEMAVQDVK
HVTITGRLCKSVFVMVLCSVEELALAHYRRSGFDQGIHGEGSTFSTLYGL
LLWDIIFMDGIPDVFRNACQAFPLDLCTDSFFTSRRPALEARLQLIHDAP
EESLRAWVAATWHEQEGRVASLVSWDRFTSLQQAQDLVSCLGGPVLSGVC
RHLAADFRHCRGGLPDLVVWNSQSRHFKLVEVKGPNDRLSHKQMIWLAEL
QKLGAEVEVCHVVAV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4ri9 DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R679 H681 R710 L713 Q717 R749 R982
Binding residue
(residue number reindexed from 1)		R301 H303 R332 L335 Q339 R371 R588
Binding affinityPDBbind-CN: Kd=0.4nM
Enzymatic activity
Enzyme Commision number 3.1.21.-
3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0036297 interstrand cross-link repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ri9, PDBe:4ri9, PDBj:4ri9
PDBsum4ri9
PubMed25430771
UniProtQ9Y2M0|FAN1_HUMAN Fanconi-associated nuclease 1 (Gene Name=FAN1)

[Back to BioLiP]