Structure of PDB 4mm4 Chain B Binding Site BS04

Receptor Information

>4mm4 Chain B (length=499) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
ASYYVYIESWTLGFAIKFLVGLVPEPPTDPDSILRPFKEFLYSYIGVPKG
DEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAV
FLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGL
GFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFG
VANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSI
AGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWA
TGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITP
AFLAVLLVVWAREYIPTHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE

Ligand information

Ligand ID

InChI

InChI=1S/ClH/h1H/p-1

InChIKey

VEXZGXHMUGYJMC-UHFFFAOYSA-M

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Cl-]

Formula

Name

CHLORIDE ION

PDB chain

4mm4 Chain B Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4mm4 Structural basis for action by diverse antidepressants on biogenic amine transporters.
Resolution	2.886 Å
Binding residue (original residue number in PDB)	S254 N286 E287 S290
Binding residue (residue number reindexed from 1)	S247 N279 E280 S283
Annotation score	3

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0035725	sodium ion transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Biological Process

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Cellular Component

External links

PDB	RCSB:4mm4, PDBe:4mm4, PDBj:4mm4
PDBsum	4mm4
PubMed	24121440
UniProt	O67854

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