Structure of PDB 4kic Chain B Binding Site BS04

Receptor Information

>4kic Chain B (length=332) Species: 1912 (Streptomyces hygroscopicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SEAQARRAVADIFNSTLASSAIGAAWELGALDELRENGKLDVSDFAVRHD
LHEPAVVGMFTALASVGIVRREGATVVVGPYFDEANHHRSLFHWLNQGSG
ELFRRMPQVLPNENRTGKFYQRDAGAISYACREISERYFDPAFWAAVDGL
GYTPTTVADLGSGSGERLIQIARRFPGVRGLGVDIADGAIAMAEKEVAAK
GFGDQISFVRGDARTIDQVSARGEFAEVDLLTCFMMGHDFWPRENCVQTL
RKLRAAFPNVRRFLLGDATRTVGIPDRELPVFTLGFEFGHDMMGVYLPTL
DEWDGVFEEGGWRCVKKHAIDSLSVSVVFELE

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

4kic Chain B Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4kic Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Resolution	2.43 Å
Binding residue (original residue number in PDB)	H243 H295
Binding residue (residue number reindexed from 1)	H238 H290
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.281: phenylpyruvate C(3)-methyltransferase.

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity

	Biological Process
GO:0009058	biosynthetic process
GO:0017000	antibiotic biosynthetic process
GO:0032259	methylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:4kic, PDBe:4kic, PDBj:4kic
PDBsum	4kic
PubMed	24914966
UniProt	Q643C8\|MPPJ_STRHY Phenylpyruvate C(3)-methyltransferase (Gene Name=mppJ)

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