Structure of PDB 4hfd Chain B Binding Site BS04

Receptor Information
>4hfd Chain B (length=311) Species: 251221 (Gloeobacter violaceus PCC 7421) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAF
DPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLE
RFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDD
VFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP
MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVETNLPKTPYMTY
TGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFL
LANIILAFLFF
Ligand information
Ligand IDMBR
InChIInChI=1S/CHBr3/c2-1(3)4/h1H
InChIKeyDIKBFYAXUHHXCS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(Br)(Br)Br
ACDLabs 10.04
CACTVS 3.341		BrC(Br)Br
FormulaC H Br3
NameTRIBROMOMETHANE
ChEMBLCHEMBL345248
DrugBankDB03054
ZINCZINC000008101061
PDB chain4hfd Chain C Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4hfd Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		I201 A238
Binding residue
(residue number reindexed from 1)		I197 A234
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hfd, PDBe:4hfd, PDBj:4hfd
PDBsum4hfd
PubMed23591864
UniProtQ7NDN8|GLIC_GLOVI Proton-gated ion channel (Gene Name=glvI)

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