Structure of PDB 4c4n Chain B Binding Site BS04

Receptor Information
>4c4n Chain B (length=152) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKD
EENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEES
LHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE
NS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4c4n Chain B Residue 1194 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4c4n Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		E91 E127 D130 D132
Binding residue
(residue number reindexed from 1)		E52 E88 D91 D93
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:4c4n, PDBe:4c4n, PDBj:4c4n
PDBsum4c4n
PubMed24062467
UniProtQ62226|SHH_MOUSE Sonic hedgehog protein (Gene Name=Shh)

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