Structure of PDB 3onf Chain B Binding Site BS04

Receptor Information
>3onf Chain B (length=488) Species: 3873 (Lupinus luteus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMALLVEKTTSGREYKVKDMSQADFGRLEIELAEVEMPGLMASRSEFG
PSQPFKGAKITGSLHMTIQTAVLIETLTALGAEVRWCSCNIFSTQDHAAA
AIARDSAAVFAWKGETLQEYWWCTERALDWGPGGGPDLIVDDGGDTTLLI
HEGVKAEEIYEKSGQFPDPDSTDNAEFKIVLSIIKEGLKTDPKRYHKMKD
RVVGVSEETTTGVKRLYQMQANGTLLFPAINVNDSVTKSKFDNLYGCRHS
LPDGLMRATDVMIAGKVAVVAGYGDVGKGCAAALKQAGARVIVTEIDPIC
ALQATMEGLQVLTLEDVVSEADIFVTTTGNKDIIMLDHMKKMKNNAIVCN
IGHFDNEIDMLGLETHPGVKRITIKPQTDRWVFPETNTGIIILAEGRLMN
LGCATGHPSFVMSCSFTNQVIAQLELWNEKSSGKYEKKVYVLPKHLDEKV
AALHLEKLGAKLTKLSKDQADYISVPVEGPYKPFHYRY
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain3onf Chain B Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3onf High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q66 T402 G403 H404 P405
Binding residue
(residue number reindexed from 1)		Q69 T405 G406 H407 P408
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H62 S85 S90 D139 E205 N230 K235 D239 N240 C244 H350 H404 S412 Q416
Catalytic site (residue number reindexed from 1) H65 S88 S93 D142 E208 N233 K238 D242 N243 C247 H353 H407 S415 Q419
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Gene Ontology
Molecular Function
GO:0004013 adenosylhomocysteinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0033353 S-adenosylmethionine cycle
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3onf, PDBe:3onf, PDBj:3onf
PDBsum3onf
PubMed22349223
UniProtQ9SP37|SAHH_LUPLU Adenosylhomocysteinase (Gene Name=SAHH)

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