Structure of PDB 3mo0 Chain B Binding Site BS04

Receptor Information

>3mo0 Chain B (length=242) Species: 9606 (Homo sapiens)

IVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITH
LQYCVCIDDCSSSNCMCGQLSMRCPPLIFECNHACSCWRNCRNRVVQNGL
RARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYL
FDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRI
AFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3mo0 Chain B Residue 6

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3mo0 Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
• Resolution: 2.78 Å
• Binding residue (original residue number in PDB): C1074 C1080 C1084
• Binding residue (residue number reindexed from 1): C81 C87 C91
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): Y1124 Y1211
• Catalytic site (residue number reindexed from 1): Y131 Y218
• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Gene Ontology

Molecular Function

• GO:0002039 p53 binding
• GO:0008270 zinc ion binding
• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0042054 histone methyltransferase activity
• GO:0046974 histone H3K9 methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:3mo0, PDBe:3mo0, PDBj:3mo0
• PDBsum: 3mo0
• PubMed: 20434463
• UniProt: Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)