Structure of PDB 3ez3 Chain B Binding Site BS04

Receptor Information
>3ez3 Chain B (length=353) Species: 5855 (Plasmodium vivax) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FFRNMYDKYRDAFLSHLNEYSLEEEIKEHISKYYKLLFDYNCLGGKNNRG
ILVILIYEYVKNSSEWEKAACLAWCIEILQAAFLVADDIMDKGEMRRNKY
CWYLLKDVETKNAVNDVLLLYNSIYKLIEIYLRNESCYVDVIATFRDATL
KTIIGQHLDTNIFSDKYSHREIDVNNINVPEQPVIDINMINFGVYKNIVI
HKTAYYSFFLPIVCGMLLAGIANLIYKKIEDISMLMGEYFQIHDDYLDIF
GDSTKTGKVGSDIQNNKLTWPLIKTFELCSEPDKIKIVKNYGKNNLACVK
VIDSLYEQYKIRKHYESYEKAQKAKILSAINELHHEGIEYVLKYLLEILF
TGV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3ez3 Chain B Residue 1104 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ez3 Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound
Resolution2.304 Å
Binding residue
(original residue number in PDB)		D126 D130
Binding residue
(residue number reindexed from 1)		D87 D91
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K81 A121 D126 D130 R135 D198 K243 F283 D287 D288
Catalytic site (residue number reindexed from 1) K46 A82 D87 D91 R96 D159 K202 F240 D244 D245
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ez3, PDBe:3ez3, PDBj:3ez3
PDBsum3ez3
PubMed
UniProtA5K4U6

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