Structure of PDB 3c5g Chain B Binding Site BS04

Receptor Information
>3c5g Chain B (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVT
SYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGA
GTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATE
IEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIF
SRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVV
PYSEFACALLYFTGSAHFNRSMKALAKTKGMSLSEHALSTAVVRHGCKVG
PGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3c5g Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase lambda.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y267 W274 R275 G278 Y279 G304 G306 R308 M309 K312
Binding residue
(residue number reindexed from 1)		Y23 W30 R31 G34 Y35 G60 G62 R64 M65 K68
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D183 D185 D246
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3c5g, PDBe:3c5g, PDBj:3c5g
PDBsum3c5g
PubMed18369368
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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