Structure of PDB 3bje Chain B Binding Site BS04

Receptor Information

>3bje Chain B (length=327) Species: 5691 (Trypanosoma brucei)

DLPIGKDGTTLHLKCKSDELADRIIFVGDPGRVDVISGYFDKDSIRASRD
HREIRFATGTYKGTPVTVISTGMGVDNIEIVLNEIHALKEYDMERGQWRH
RKGDADAPSAGPFFDPSTMKIIRLGTCGSPAESVPPLALAVTRHAIGMDN
TSLYYSAGTRETSKDQQEIRRIVREQTGLRAIDIYTSMAHPNITKSICAA
CDAHNAATGSEADKQQYVIGTTATASGFYGCQGRRVGRFMKHLTVPNMVE
ELGSLKFNLSNGVEVVTNIEMETSAICYLSDMLGYQAGAACVVVSKRVGE
KKMFLGDQLDAAMKRCIKIILEALVSA

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 3bje Chain B Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3bje The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase
• Resolution: 1.44 Å
• Binding residue (original residue number in PDB): M87 D90 N91
• Binding residue (residue number reindexed from 1): M73 D76 N77
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.2.-

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004731 purine-nucleoside phosphorylase activity
• GO:0004850 uridine phosphorylase activity
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006218 uridine catabolic process
• GO:0009116 nucleoside metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0097014 ciliary plasm

External links

• PDB: RCSB:3bje, PDBe:3bje, PDBj:3bje
• PDBsum: 3bje
• PubMed: 20070944
• UniProt: Q57VZ2