Structure of PDB 2z87 Chain B Binding Site BS04

Receptor Information
>2z87 Chain B (length=591) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVIDIDAATKIMCSNAKAISLNEVEKNEIISKYREITAKKSERAELKEVE
PIPLDWPSDLTLPPLPESTNDYVWAGKRKQLIIDGLSIVIPTYNRAKILA
ITLACLCNQKTIYDYEVIVADDGSKENIEEIVREFESLLNIKYVRQKDYG
YQLCAVRNLGLRAAKYNYVAILDCDMAPNPLWVQSYMELLAVDDNVALIG
PRKYIDTSKHTYLDFLSQKSLINEIPEIITNQNKSVDWRIEHFKNTDNLR
LCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFTHWGGEDNEFGYRLYREGC
YFRSVEGAMAYHQEPPGKLLQQKVPYFYRKKEKIESATLKRVPLVSIYIP
AYNCSKYIVRCVESALNQTITDLEVCICDDGSTDDTLRILQEHYANHPRV
RFISQKNKGIGSASNTAVRLCRGFYIGQLDSDDFLEPDAVELCLDEFRKD
LSLACVYTTNRNIDREGNLISNGYNWPIYSREKLTSAMICHHFRMFTARA
WNLTEGFNESISNAVDYDMYLKLSEVGPFKHINKICYNRVLHNTSIKKLD
IQKENHFKVVNESLSRLGIKKYKYSPLTNLNECRKYTWEKI
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2z87 Chain B Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2z87 Crystal structure of chondroitin polymerase from Escherichia coli K4.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D521 H631
Binding residue
(residue number reindexed from 1)		D432 H542
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.175: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase.
2.4.1.226: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2z87, PDBe:2z87, PDBj:2z87
PDBsum2z87
PubMed18771653
UniProtQ8L0V4|CHS_ECOLX Chondroitin synthase (Gene Name=kfoC)

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