Structure of PDB 2yz5 Chain B Binding Site BS04

Receptor Information

>2yz5 Chain B (length=265) Species: 274 (Thermus thermophilus)

MVDSHVHTPLCGHAEGHPEAYLEEARAKGLKGVVFTDHSPMPPWYDPESR
MRLEALPFYLLALERVRERAQDLYVGIGLEADFHPGTEGFLAQLLRRYPF
DYVIGSVHYLGAWPLDHPDHQEEYAWRDLKEVFRAYFQEVEKAARSGLFH
AIGHLDLPKKFGHRLPEEALLELAEPALRAVAEAGLFLDVNTAGLRRPAK
EVYPAPALLRRARELGIGLVLGSDAHRPEEVGFAFPEVQALLAGLGFREA
YYFVEGSPVAYPLSR

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 2yz5 Chain B Residue 2002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2yz5 Crystal Structure of Monofunctional Histidinol Phosphate Phosphatase from Thermus thermophilus HB8.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): H7 H38 H108 H226
• Binding residue (residue number reindexed from 1): H7 H38 H108 H226
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.15: histidinol-phosphatase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004401 histidinol-phosphatase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000105 L-histidine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2yz5, PDBe:2yz5, PDBj:2yz5
• PDBsum: 2yz5
• PubMed: 17929834
• UniProt: Q5SLG2