Structure of PDB 2uzh Chain B Binding Site BS04

Receptor Information

>2uzh Chain B (length=153) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LPRVGLGTDVHPIEAGRPCRLLCLEFDDADGCASDGDVAAHALCDALLSA
AGLGDLGTIFGTDRPQWRGASGADMIRHVRGLVENAGFVIGNATVQVIGN
RPKVGPRREEAQQVLSELVGAPVSVSATTTDGLGLTGRGEGLAAIATALV
AAE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2uzh Chain C Residue 1157 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2uzh The Structure of Mycobacteria 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase, an Essential Enzyme, Provides a Platform for Drug Discovery.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	D11 H13 H45
Binding residue (residue number reindexed from 1)	D9 H11 H41
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0008685	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829	lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0008299	isoprenoid biosynthetic process
GO:0016114	terpenoid biosynthetic process
GO:0019288	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

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Biological Process

External links

PDB	RCSB:2uzh, PDBe:2uzh, PDBj:2uzh
PDBsum	2uzh
PubMed	17956607
UniProt	A0R559

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