Structure of PDB 1zp0 Chain B Binding Site BS04

Receptor Information
>1zp0 Chain B (length=239) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDST
LTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVI
KDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYEC
ILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQD
PFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE
Ligand information
Ligand IDTTF
InChIInChI=1S/C8H5F3O2S/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
InChIKeyTXBBUSUXYMIVOS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1cc(sc1)C(=O)CC(=O)C(F)(F)F
ACDLabs 10.04O=C(c1sccc1)CC(=O)C(F)(F)F
CACTVS 3.341FC(F)(F)C(=O)CC(=O)c1sccc1
FormulaC8 H5 F3 O2 S
Name4,4,4-TRIFLUORO-1-THIEN-2-YLBUTANE-1,3-DIONE;
2-THENOYLTRIFLUOROACETONE
ChEMBLCHEMBL1236433
DrugBankDB04795
ZINCZINC000100004957
PDB chain1zp0 Chain C Residue 308 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1zp0 Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II
Resolution3.5 Å
Binding residue
(original residue number in PDB)		P169 W173 H216
Binding residue
(residue number reindexed from 1)		P161 W165 H208
Annotation score1
Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0048039 ubiquinone binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006121 mitochondrial electron transport, succinate to ubiquinone
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0031966 mitochondrial membrane
GO:0045273 respiratory chain complex II (succinate dehydrogenase)

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1zp0, PDBe:1zp0, PDBj:1zp0
PDBsum1zp0
PubMed15989954
UniProtQ007T0|SDHB_PIG Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Gene Name=SDHB)

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