Structure of PDB 1xhv Chain B Binding Site BS04

Receptor Information
>1xhv Chain B (length=252) Species: 727 (Haemophilus influenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFIKPIYQDINSILIGQKVKRPKSGHAAGEPFEKLVYKFLKENLSDLTFK
QYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLF
EEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKM
IDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAA
MQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKK
YI
Ligand information
Receptor-Ligand Complex Structure
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PDB1xhv Mechanistic Insights from the Structures of HincII Bound to Cognate DNA Cleaved from Addition of Mg(2+) and Mn(2+)
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H73 E74 Y77 K93 Q109
Binding residue
(residue number reindexed from 1)		H68 E69 Y72 K88 Q104
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:1xhv, PDBe:1xhv, PDBj:1xhv
PDBsum1xhv
PubMed15476804
UniProtP17743|T2C2_HAEIF Type II restriction enzyme HincII (Gene Name=hincIIR)

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