Structure of PDB 1bqo Chain B Binding Site BS04
Receptor Information
>1bqo Chain B (length=173) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
FRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF
SRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDD
DEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRF
RLSQDDINGIQSLYGPPPDSPET
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
1bqo Chain B Residue 304 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1bqo
Discovery of potent, achiral matrix metalloproteinase inhibitors.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
D107 D182 E184
Binding residue
(residue number reindexed from 1)
D25 D100 E102
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
H201 E202 H205 H211
Catalytic site (residue number reindexed from 1)
H119 E120 H123 H129
Enzyme Commision number
3.4.24.17
: stromelysin 1.
Gene Ontology
Molecular Function
GO:0004222
metalloendopeptidase activity
GO:0008237
metallopeptidase activity
GO:0008270
zinc ion binding
Biological Process
GO:0006508
proteolysis
Cellular Component
GO:0031012
extracellular matrix
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1bqo
,
PDBe:1bqo
,
PDBj:1bqo
PDBsum
1bqo
PubMed
9733482
UniProt
P08254
|MMP3_HUMAN Stromelysin-1 (Gene Name=MMP3)
[
Back to BioLiP
]