Structure of PDB 8urb Chain A Binding Site BS04

Receptor Information
>8urb Chain A (length=921) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMAYLNRVRGSSAARLEPCNGTDTQHVYRAFDIYNKDVACLGKFLKVNCV
RLKNLDKHDAFYVVKRCTKSAMEHEQSIYSRLEKCGAVAEHDFFTWKDGR
AIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEESYFN
NKVWFDPVENEDIHRVYALLGTIVSRAMLKCVKFCDAMVEQGIVGVVTLD
NQDLNGDFYDFGDFTCSIKGMGIPICTSYYSYMMPVMGMTNCLASECFVK
SDIFGEDFKSYDLLEYDFTEHKTALFNKYFKYWGLQYHPNCVDCSDEQCI
VHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNN
DLNLHSSRLSINELLQFCSDPALLIASSPALVDQRTVCFSVAALGTGMTN
QTVKPGHFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKGDAAVKDFDYYR
YNRPTVLDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLN
KFGKAGLYYESLSYEEQDELYAYTKRNILPTMTQLNLKYAISGKERARTV
GGVSLLSTMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKNLID
GVENPCLMGWDYPKCDRALPNMIRMISAMILGSKHTTCCSSTDRFFRLCN
ELAQVLTEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSANVNKL
LSVDSNVCHNLEVKQLQRKLYECCYRSTTVDDQFVVEYYGYLRKHFSMMI
LSDDGVVCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINK
GPHEFCSQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLE
RYVSLAIDAYPLSKHENPEYKKVFYVLLDWVKHLYKTLNAGVLESFSVTL
LEDSTAKFWDESFYANMYEKS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8urb Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8urb An alphacoronavirus polymerase structure reveals conserved co-factor functions.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		H637 C640
Binding residue
(residue number reindexed from 1)		H635 C638
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8urb, PDBe:8urb, PDBj:8urb
PDBsum8urb
PubMed36993498
UniProtU6BRU0

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