Structure of PDB 8s3e Chain A Binding Site BS04

Receptor Information
>8s3e Chain A (length=902) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCAEVGWMTSVKDWAG
VMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQI
DMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRS
WLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGF
IHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRL
FMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHIT
LESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQ
GSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHP
KIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQG
LSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPT
VCELCFVKLKLLMIAIEYKRILINPGNHLKIQEGTLGFFIASDAKEVKRA
FFYCKACHDVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCI
FGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNF
PKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILA
SLNIKSMQFDDITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQP
FACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENA
LRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYN
MLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHN
AG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8s3e Chain A Residue 1206 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s3e Cryo-EM structure of the Slo1 potassium channel with the auxiliary gamma 1 subunit suggests a mechanism for depolarization-independent activation.
Resolution2.39 Å
Binding residue
(original residue number in PDB)		Q889 D892 D895 D897
Binding residue
(residue number reindexed from 1)		Q731 D734 D737 D739
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005267 potassium channel activity
GO:0046872 metal ion binding
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8s3e, PDBe:8s3e, PDBj:8s3e
PDBsum8s3e
PubMed38553946
UniProtQ9BG98|KCMA1_RABIT Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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