Structure of PDB 8r6w Chain A Binding Site BS04

Receptor Information
>8r6w Chain A (length=1974) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSEELEAISRALSFFSLFEPNIERVEGTFPNSEIKMLEQFLSTPA
DVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEINRCEAIDKTQDL
LAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDSGFGSLMDHGAY
GELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPITYRRFKPALSSSAR
QEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIGDFLTFNNLLT
DSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNLSSNVVQWSLW
VSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKSSSHIFYSLGI
RKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLVNLPCTMLNSI
AFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTEEIITLTRYTQ
MEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCMVRIASQPFSL
IPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEESTELNALGEM
YKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAACSSLEREIAQR
HGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWELYSEVQTKEYH
RSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICLFKKNQHGGLR
EIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIENHGLKSA
RSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFIWAAISM
FRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSWMDKGRT
YIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESISGVVD
VIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGIYSSEK
STVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQEDYSN
LLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGMLISDPD
PALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEIQGKTKGD
EDYRALDATSGGTLSHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPG
VLYRRAANKKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHC
FRFSTQKASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLL
EEVEHLTGKFVVRERNIVRSRIDLFQEPVDLRCKAEDLVSEVWFGLKRTK
LGPRLLKEEWDKLRASFAWLSTDPSETLRDGPFLSHVQFRNFIAHVDAKS
RSVRLLGAPVTTISQVVRMNFFPGFSLEAEESISILKHVLFMVLNGPYTE
EYKLEMIIEAFSTLVIPQPSEVIRKSRTMTLCLLSNYLSSRGGSILDQIE
RAQSGTLGGFSKPQKTFVRPGGGVGYKGKGVWTGVMEDTHVQILIDGDGT
SNWLEEIRLSSDARLYDVIESIRRLCDDLGINNRVASAYRGHCMVRLSGF
KIKPASRTDGCPVRIMNPDEVKMRVRGDILNLSVTIQEGRVMNILSYRPR
DTDISESAAAYLWSNRDLFSFGKKEPSCSWICLKTLDNWAWSHASVLLAN
DRKTQGIDNRAMGNIFRDCLEGSLRKQGLMRSKLIAVELSEGSLDIESIF
DGAPILWSAEVEEFGEGVVAVSYSSKYYHLTLMDQAAITMCAIMGKEGCR
GLLTEKRCMAAIREQVRPFLIFLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8r6w Structural snapshots of phenuivirus cap-snatching and transcription
Resolution3.35 Å
Binding residue
(original residue number in PDB)		K1668 F1703 P1706 Q1707 R1712 G1716 V1717 Y1719 L1772 G1773 N1834 N1846 R1851
Binding residue
(residue number reindexed from 1)		K1625 F1660 P1663 Q1664 R1669 G1673 V1674 Y1676 L1729 G1730 N1781 N1793 R1798
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8r6w, PDBe:8r6w, PDBj:8r6w
PDBsum8r6w
PubMed38709882
UniProtI0DF35|L_SFTS RNA-directed RNA polymerase L

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