Structure of PDB 8q7h Chain A Binding Site BS04

Receptor Information
>8q7h Chain A (length=1403) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LMVPLRLQAYPEELIRQRHDGHPEYLIRWSVLKCEHILMWLSAPEVYANC
PGLLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYA
SIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAH
VLLSLSQQHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFS
LVKRYLCVTSLLDQLNSRGQRELEFSMAVGNLISELVRSMGWARPTRSIF
QPLYPLPYLQPTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLGEISVSVE
MAESLLQVLSSRFEGSTLNDLLNSQIYTKYRPLLKRLQQETQPFLLLLRT
LDAPNKTLLLSVLRVITRLLDFPEAMVLPWHEVLEPCLNCLSDSEIVQEL
TCFLHRLASHKDYAVVLCCLGAKEILSKVLDKHGCELRDLVTECEKYAQL
YSNLTSSILAGCIQMVLGQIEDHRRTHQPINIPFFDVFLRHLCQFWPLFR
EQLCRRTCLFYTIRAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRF
LPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALGWLLDQYLEQRET
SRNPLSRAASFASRVRRLCHLLVHVEPPSSSLRNITQCWLSVVQEQVSRF
LAAAWRAPDFVPRYCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQ
SFLTAAHMSEQFARYIDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSGL
ELATTFEHFYQHYMADRLLSFSWLEGAVLEQIGLCFPNRLPQLMLQSLST
SEELQRQFHLFQLQRLDKLFLEQEDEPSPAISILVLSPRCWPVSPLCYLY
HPRKCLPTEFCDALDRFSSFYSQSQNHVLDMGPHRRLQWTWLGRAELQFG
KQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPLTSGN
GPLTLHEGVLRLHEPGSGEALWLIPPQAYLNVERTLEQKRNLLSCLLVRI
LKAHGEKGLHIDQLVCLVLEAWQKGPNPGHTVAVACTSTDVLSCILHLLG
QGYVKRQILMYAAMGPCRGQAEAVATLASLQLGRTMSPQEVEGLMKQTVR
QVQETLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLHCPVCVSP
LGCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAIVS
SPEVISKYEKALLRGYVESCSNLTWCTNGCDRILCRQGLGCGTTCSKCGW
ASCFNCSFPEAHYPASCGHMSQWVDDGGYYDRFQDYNERCTFHHQAREFA
VNLRNRVSAIHVPPPRSFTFLNDACQGLEQARKVLAYACVYSMDVVEQQT
ENLELHTNALQILLEETLLRDLASSLRLLDCLSTGMELLRRIQERLLAIL
QHS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8q7h Chain A Residue 2604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8q7h Noncanonical assembly, neddylation and chimeric cullin RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Resolution4.1 Å
Binding residue
(original residue number in PDB)		C2160 C2181
Binding residue
(residue number reindexed from 1)		C1226 C1245
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007088 regulation of mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8q7h, PDBe:8q7h, PDBj:8q7h
PDBsum8q7h
PubMed38605244
UniProtQ8IWT3|CUL9_HUMAN Cullin-9 (Gene Name=CUL9)

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