Structure of PDB 8pj9 Chain A Binding Site BS04

Receptor Information
>8pj9 Chain A (length=1051) Species: 1268061 (Streptococcus thermophilus DGCC 7710) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPYSIGLDIGTNSVGWAVITDNYKVPSKKMKVLGNTSKKYIKKNLLGVLL
FDSGITAEGRRLKRTARRRYTRRRNRILYLQEIFSTEMATLDDAFFQRLD
DSFLVPDDKRDSKYPIFGNLVEEKVYHDEFPTIYHLRKYLADSTKKADLR
LVYLALAHMIKYRGHFLIEGEFNVTDNETEAPLSSAMIKRYNEHKEDLAL
LKEYIRNISLKTYNEVFKDDTKNGYAGYIDGKTNQEDFYVYLKNLLAEFE
GADYFLEKIDREDFLRKQRTFDNGSIPYQIHLQEMRAILDKQAKFYPFLA
KNKERIEKILTFRIPYYVGPLARGNSDFAWSIRKRNEKITPWNFEDVIDK
ESSAEAFINRMTSFDLYLPEEKVLPKHSLLYETFNVYNELTKVRFIAESM
RDYQFLDSKQKKDIVRLYFKDKRKVTDKDIIEYLHAIYGYDGIELKGIEK
QFNSSLSTYHDLLNIINDKEFLDDSSNEAIIEEIIHTLTIFEDREMIKQR
LSKFENIFDKSVLKKLSRRHYTGWGKLSAKLINGIRDEKSGNTILDYLID
DGISNRNFMQLIHDDALSFKKKIQKAQIIGDEDKGNIKEVVKSLPGSPAI
KKGILQSIKIVDELVKVMGGRKPESIVVEMATKHVARLLDEKFNNKKDEN
NRAVRTVKIITLKSTLVSQFRKDFELYKVREINDFHHAHDAYLNAVIASA
LLKKYPKLEPEFVYGSNIMNIFKKSRPLIEVNEETGESVWNKESDLATVR
RVLSYPQVNVVKKVEEQNHGLDRGKPKGLFNANLSSKPKPNSNENLVGAK
EYLDPKKYGGYAGISNSFAVLVKGTIEKGAKKKITNVLEFQGISILDRIN
YRKDKLNFLLEKGYKDIELIIELPKYSLFELSDGSRRMLASILSTNNKRG
EIHKGNQIFLSQKFVKLLYHAKRISNTINENHRKYVENHKKEFEELFYYI
LEFNENYVGAKKNGKLLNSAFQSWQNHSIDELCSSFIGPTGSERKGLFEL
TSRGSAADFEFLGVKIPRYRDYTPSSLLKDATLIHQSVTGLYETRIDLAK
L
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pj9 Structural basis for spacer acquisition in a type II-A CRISPR-Cas system
Resolution3.24 Å
Binding residue
(original residue number in PDB)		L169 I492 M495 K526 T656 M693 Q694 H697 P729 K936
Binding residue
(residue number reindexed from 1)		L167 I358 M361 K392 T522 M559 Q560 H563 P595 K633
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8pj9, PDBe:8pj9, PDBj:8pj9
PDBsum8pj9
PubMed
UniProtG3ECR1|CAS9_STRTR CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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