Structure of PDB 8ovj Chain A Binding Site BS04

Receptor Information
>8ovj Chain A (length=255) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHE
AGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNV
LPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLP
SGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRG
VARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKA
VKGAW
Ligand information
>8ovj Chain 2 (length=1105) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaug
cucugguacauagagaaagguacacucagggaagucggcaaaauagaugc
guaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucaga
acugcuuacggcggggaauccaacuguauaauuaaaacauagguuuguga
ugcauccaagugguguauaucgcaaacugauuucugcccagugcucugaa
ugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacu
augacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgc
augaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaa
cgacagucaagggaacggacuugaagggcuaagcggggaaagaagacccu
guugaguuugacuccagucuggcucugugcggcgacauccguugcuucac
uuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccg
ucuagguuguggguacccaaccgugcuguaaacugaaccaacgggaguuc
cggagucuuguuucgagacaucugccagauggggaguuuggcuggggcgg
cauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaa
cagaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuc
caguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaagaa
uaggaaauaugaacaaaucauaccagaggugucagaauaauuaccacagg
gauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugau
ccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaagggu
uggauuguucacccacugacagggaacgugagcuggguuuagaccgucgu
gagacagguugguuuuacccuacuuagcuggaaauugcgagaaaaagauu
auccgugcaaagcggacguggcgagcgguggguaguacaugguacgcuca
ucacc
.......................<<......>>......<<<<<...>>>
>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<
....<<..>>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>
.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<..
..<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....
<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<....
...>>>>>>........<...........<<<<<.......>>>>>....
.>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>......
......<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<
<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>
...<<<<<.....<<<<....<<...<<<<<<<<<..>>>>>>>>>.>>.
....<<<............>>>...................<<<<...>>
>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
....>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.
......>>>>>..>>.<<<....>>>.>>.........<<<<<.......
.......<<<<.......>>>>.>>>>>..........>>>>..>>>>>>
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.
<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....>>..>>>.>>>>>>>.....................
..<<<<.....>>>>.<<<.>>>.<.<<<<<<<.<<<<...>>>>>>>>>
>>.>.
Receptor-Ligand Complex Structure
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PDB8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.4 Å
Binding residue
(original residue number in PDB)
G2 C8 G11 N12 V18 G20 R23 G25 Y34 R37 Y40 R54 R64 Y67 F69 R71 F83 G85 P95 T125 L126 A127 R128 A129 S130 D132 L150 P151 S152 K156 R174 V179 L180 S185 R193 W196 K198 V199 R200 G201 V202 H211 G214 N215 H216 Q217 H218 I219 G220 H221 P222 S223 T224 R227 H228 P230 G232 Q233 K234 G236 I238 A240 R241 R242 T243 G244 I246 K253 G254
Binding residue
(residue number reindexed from 1)
G1 C7 G10 N11 V17 G19 R22 G24 Y33 R36 Y39 R53 R63 Y66 F68 R70 F82 G84 P94 T124 L125 A126 R127 A128 S129 D131 L149 P150 S151 K155 R173 V178 L179 S184 R192 W195 K197 V198 R199 G200 V201 H210 G213 N214 H215 Q216 H217 I218 G219 H220 P221 S222 T223 R226 H227 P229 G231 Q232 K233 G235 I237 A239 R240 R241 T242 G243 I245 K252 G253
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
PDBsum8ovj
PubMed38722744
UniProtQ4FWX5

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