Structure of PDB 8jut Chain A Binding Site BS04

Receptor Information
>8jut Chain A (length=4308) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCESGLFLCPA
EGTCIPSSWVCDEDKDCSDGADEQQNCAKEFECGSGECILRAYVCDHDND
CEDNSDERNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCE
SNQSHHRCYPREWACPGSGRCISIDKVCDGVPDCPEGDDENNVTSGRTCG
MGVCSVLNCEYQCHQTPFGGECFCPPGHIINSNDSRTCIDFDDCQIWGIC
DQKCENRQGRHQCLCEEGYILERGQHCKSSDSFSAASVIFSNGRDLLVGD
LHGRNFRILAESKNRGMVMGVDFHYQKHRVFWTDPMQEKVFSTDINGLNT
QEILNVSVDTPENLAVDWINNKLYLVETKVNRIDVVNLEGNQRVTLITEN
LGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKVGW
PAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGIS
LFEEHVFFTDWTKMAVMKASKFTETNPQVYHQSSLRPHGVTVYHALRQPN
ATNPCGSNNGGCAQVCVLSHRTDNGGLGYRCKCEFGFELDDDEHRCVAVK
NFLLFSSKTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTVFYS
DLSKDIIYKQKIDGTGKEVITANRLESVECLTFDWISRNLYWTDGGLKSV
TVLRLADKSRRQIISNLNNPRSIVVHPTAGYMFLSDWFRPAKIMRAWSDG
SHLMPIVNTSLGWPNGLAIDWSASRLYWVDAFFDKIEHSTLDGLDRKRLG
HVDQMTHPFGLTVFKDNVFITDWRLGAIIRVRKSDGGDMTVIRRGISSVM
HVKAYDADLQTGSNYCSQTTHANGDCSHFCFPVPNFQRVCGCPYGMKLQR
DQMTCEGDPAREPPTQQCGSLSFPCNNGKCVPSFFRCDGVDDCHDNSDEH
QCGVFNNTCSPSAFACVRGGQCIPGQWHCDRQNDCLDGSDEQNCPTHATS
STCPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNCQASGTCQPTQFRC
PDHRCISPLYVCDGDKDCADGSDEAGCVLNCTSAQFKCADGSSCINSRYR
CDGVYDCRDNSDEAGCPTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDC
IHGSDEHTGCVPKTCSPTHFLCDNGNCIYKAWICDGDNDCRDMSDEKDCP
TQPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHF
NGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVN
MRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAHTH
NLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDS
GLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRG
LALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSID
YPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVY
WTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCAS
ASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNII
FGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKT
DGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRY
GKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMD
GTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMIL
VHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRG
LRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGR
SCSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVAN
GFIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAA
GNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFW
ADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLD
LIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQ
PGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHF
CFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPR
DHSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSS
SPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARV
SKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGL
ALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQYIY
WTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNPCD
QFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFT
CLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPY
HYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCNGINNC
HDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENP
IYCASHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSVNT
CRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSSTQFTC
VNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSCANGRC
VRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDN
DCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSD
EKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDE
CKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPYLIFSN
RYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQIIERMF
LNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRK
MIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTN
KSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDG
SLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIH
VYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDR
TLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRL
GQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQCANKR
CIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCD
VDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDC
RDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCV
PRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQC
TSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCI
QSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNG
VDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCISQHYVCDNVNDCGD
LSDETGCNLGDNRTCAENICEQNCTQLSSGGFICSCRPGFKPSTLDKNSC
QDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPL
LLLPENVRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTV
LAQGSQFGAIKRAYIPNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRH
IYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQG
KQPKIESAWMNGEHRSVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIE
AIKYDGTDRRLIINEAMKPFSLDIFEDKLYWVAKEKGEVWRQNKFGKENK
EKVLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQ
GSDFVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGY
SGEYCEVG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jut Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution4.2 Å
Binding residue
(original residue number in PDB)
N2097 F2115 R2149 R2194 Y2210
Binding residue
(residue number reindexed from 1)
N1990 F2008 R2042 R2087 Y2103
External links
PDB RCSB:8jut, PDBe:8jut, PDBj:8jut
PDBsum8jut
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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