Structure of PDB 8jpx Chain A Binding Site BS04

Receptor Information
>8jpx Chain A (length=770) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKAIVVINLVKINKKIIPDKIYVYRLFNDPEEELQKEGYSIYRLAYENVG
IVIDPENLIIATTKELEYEGEFIPEGEISFSELRNDYQSKLVLRLLKENG
IGEYELSKLLRKFRKPKTFGDYKVIPSVEMSVIKHDEDFYLVIHIIHQIQ
SMKTLWELVNKDPKELEEFLMTHKENLMLKDIASPLKTVYKPCFEEYTKK
PKLDHNQEIVKYWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFA
SKIKKNKNYKIYLLPQLVVPTYNAEQLESDVAKEILEYTKLMPEERKELL
ENILAEVDSDIIDKSLSEIEVEKIAQELENKIRVRDDKGNSVPISQLNVQ
KSQLLLWTNYSRKYPVILPYEVPEKFRKIREIPMFIILDSGLLADIQNFA
TNEFRELVKSMYYSLAKKYNSLAKKARSTNEIGLPFLDFRGKEKVITEDL
NSDKGIIEVVEQVSSFMKGKELGLAFIAARNKLSSEKFEEIKRRLFNLNV
ISQVVNEDTLKNKRDKYDRNRLDLFVRHNLLFQVLSKLGVKYYVLDYRFN
YDYIIGIDVAPMKRSEGYIGGSAVMFDSQGYIRKIVPIKIGEQRGESVDM
NEFFKEMVDKFKEFNIKLDNKKILLLRDGRITNNEEEGLKYISEMFDIEV
VTMDVIKNHPVRAFANMKMYFNLGGAIYLIPHKLKQAKGTPIPIKLAKKR
IIKNGKVEKQSITRQDVLDIFILTRLNYGSISADMRLPAPVHYAHKFANA
IRNEWKIKEEFLAEGFLYFV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8jpx Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jpx Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonautre
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D558 H745
Binding residue
(residue number reindexed from 1)		D558 H745
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jpx, PDBe:8jpx, PDBj:8jpx
PDBsum8jpx
PubMed38295801
UniProtQ8U3D2|AGO_PYRFU Protein argonaute (Gene Name=ago)

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