Structure of PDB 8ili Chain A Binding Site BS04

Receptor Information

>8ili Chain A (length=177) Species: 10498 (African swine fever virus BA71V)

GGGMLTLIQGKKIVNHLRSRLAFEYNGQLIKILSKNIVAVGSLRREEKML
NDVDLLIIVPEKKLLKHVLPNIRIKGLSFSVKVCGERKCVLFIEWEKKTY
QLDLFTALAEEKPYAIFHFTGPVSYLIRIRAALKKKNYKLNQYGLFKNQT
LVPLKITTEKELIKELGFTYRIPKKRL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8ili Chain A Residue 204

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ili Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D49 D51 D100
• Binding residue (residue number reindexed from 1): D52 D54 D103
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006281 DNA repair
• GO:0006303 double-strand break repair via nonhomologous end joining
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:8ili, PDBe:8ili, PDBj:8ili
• PDBsum: 8ili
• PubMed: 37958741
• UniProt: P42494|DPOLX_ASFB7 Repair DNA polymerase X (Gene Name=Ba71V-97)