Structure of PDB 8g6r Chain A Binding Site BS04

Receptor Information
>8g6r Chain A (length=899) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DMAYLNRVRGSSAARLEPCNGTDTQHVYRAFDIYNKDVACLGKFLKVNCV
RLKNLDKHDAFYVVKRCTKSAMEHEQSIYSRLEKCGAVAEHDFFTWKDGR
AIYGNVCRKDLTEYTMMDLCYALRNFDENNCDVLKSILIKVGACEESYFN
NKVWFDPVENEDIHRVYALLGTIVSRAMLKCVKFCDAMVEQGIVGVVTLD
NQDLNGDFYDFGDFTCSIKGMGIPICTSYYSYMMPVMGMTNCLASECFVK
SDIFGEDFKSYDLLEYDFTEHKTALFNKYFKYWGLQYHPNCVDCSDEQCI
VHCANFNTLFSTTIPITAFGPLCRKCWIDGVPLVTTAGYHFKQLGIVWNN
DLNSINELLQFCSDPALLIASSPALVDQRTVCFSVAALGTGMTNQTVKPG
HFNKEFYDFLLEQGFFSEGSELTLKHFFFAQKGDAAVKDFDYYRYNRPTV
LDICQARVVYQIVQRYFDIYEGGCITAKEVVVTNLNKSAGYPLNKFGKAG
LYYESLSYEEQDELYAYTKRNILPTMTQLNLKYAISGKERARTVGGVSLL
STMTTRQYHQKHLKSIVNTRGASVVIGTTKFYGGWDNMLKNLIDGVENPC
LMGWDYPKCDRALPNMIRMISAMILGSKHTTCCSSTDRFFRLCNELAQVL
TEVVYSNGGFYLKPGGTTSGDATTAYANSVFNIFQAVSANVNKLLSVDSN
VCHNLEVKQLQRKLYECCYRSTTVDDQFVVEYYGYLRKHFSMMILSDDGV
VCYNNDYASLGYVADLNAFKAVLYYQNNVFMSASKCWIEPDINKGPHEFC
SQHTMQIVDKDGTYYLPYPDPSRILSAGVFVDDVVKTDAVVLLERYVSLA
IDAYPLSKHENPEYKKVFYVLLDWVKHLYKTLTAKFWDESFYANMYEKS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8g6r Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8g6r An alphacoronavirus polymerase structure reveals conserved co-factor functions.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		H637 C640 C641
Binding residue
(residue number reindexed from 1)		H629 C632 C633
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8g6r, PDBe:8g6r, PDBj:8g6r
PDBsum8g6r
PubMed36993498
UniProtA0A0U2C263

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