Structure of PDB 8fbg Chain A Binding Site BS04

Receptor Information
>8fbg Chain A (length=217) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRM
LLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKG
EFVNECVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNY
ARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGN
GKTVCKCGAPNCSGFLG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8fbg Chain A Residue 3004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fbg Crystal structure of NSD1
Resolution2.29 Å
Binding residue
(original residue number in PDB)		C1793 C1818 C1823
Binding residue
(residue number reindexed from 1)		C30 C55 C60
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Gene Ontology
Molecular Function
GO:0042054 histone methyltransferase activity
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:8fbg, PDBe:8fbg, PDBj:8fbg
PDBsum8fbg
PubMed
UniProtO88491|NSD1_MOUSE Histone-lysine N-methyltransferase, H3 lysine-36 specific (Gene Name=Nsd1)

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