Structure of PDB 8eik Chain A Binding Site BS04

Receptor Information

>8eik Chain A (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EDQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRF
LELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGT
AAEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPK
LYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIA
VGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARK
GLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISR
FLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEY
NRIAKLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNM
GRGARQKLLGRSWSVPVIRHLFAPLKDYFACE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8eik Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8eik Cryo-EM structure of human DNMT3B homo-hexamer
Resolution	3.19 Å
Binding residue (original residue number in PDB)	C490 C495 C524
Binding residue (residue number reindexed from 1)	C78 C83 C112
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0009008	DNA-methyltransferase activity

	Biological Process
GO:0010468	regulation of gene expression

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Molecular Function

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Biological Process

External links

PDB	RCSB:8eik, PDBe:8eik, PDBj:8eik
PDBsum	8eik
PubMed	37941146
UniProt	Q9UBC3\|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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