Structure of PDB 8de9 Chain A Binding Site BS04

Receptor Information
>8de9 Chain A (length=259) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVMKWKTVLAIFLLVVLYLIIGATVFKALEQPEEGLQKYRIIQEKIDFLS
MHTCVQTSELEDLVKQVVLAIRAGVNPSGHPSQESSMWDLSSSFFFAGTV
ITTIGFGNVSPHTEGGRIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGI
AKVEKMFVKWNVSQTKIRVTSTVLFILFGCLLFVALPALIFQHIEGWSAL
ESIYFVVITLTTIGFGDFVAGGSEIEYLDYYKPIVWFWILVGLAYFAAVL
SMIGDWLRV
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain8de9 Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8de9 Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		I143 G144 I252 G253
Binding residue
(residue number reindexed from 1)		I104 G105 I213 G214
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8de9, PDBe:8de9, PDBj:8de9
PDBsum8de9
PubMed36841877
UniProtF1QAI2

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