Structure of PDB 8d97 Chain A Binding Site BS04

Receptor Information
>8d97 Chain A (length=1600) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAGK
SFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFL
RKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSN
FDLDHDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRIT
LRNEHAKKLLLASLGFVDKLCGALCRIEVIKSEDHNDELRKQAEVIVEAF
KQNDKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKV
QGTALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGGVSTRFRIL
GDTEYYSKAHDSEGSDLFIPVTPPEGIETKEWIIVGRLKAATPFYFGVQQ
PSDSIPGKEKKSEDSLVINEHTSFNILLDKENRYRIPRSALRGALRRDLR
TAFGSGCNVSLGGQILCNCKVCIEMRRITLKDSVSDFSEPPEIRYRIAKN
PGTATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFPEQLSSVIRYWEENDG
KNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQKINEYIKERGMRGKEKEL
LEMGESSLPDGLIPYKFFEERECLFPYKENLKPQWSEVQYTIEVGSPLLT
ADTISALTEPGNRDAIAYKKRVYNDGNNAIEPEPRFAVKSETHRGIFRTA
VGRRTGDLGKEDHEDCTCDMCIIFGNEHESSKIRFEDLELINGNEFEKLE
KHIDHVAIDRFTGGALDKAKFDTYPLAGSPKKPLKLKGRFWIKKGFSGDH
KLLITTALSDIRDGLYPLGSKGGVGYGWVAGISIDDNVPDDFKEMINKTY
VHPGHQSPKQDHKNKNIYYPHYFLDSGSKVYREKDIITHEEFTEELLSGK
INCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFFNINGELMIPGSEL
RGMLRTHFEALTKSCFAIFGETLSWRMNADEKDYKIDSNSIRKMESQRNP
KYRIPDELQKELRNSGNGLFNRLYTSERRFWSDVSNKFENSIDYKREILR
CAGRPKNYKGGIIRQRKDSLMAEELKVHRLPLYDNFDIPDSAYKANDHCR
KSATCSTSRGCRERFTCGIKVRDKNRVFLNAANNNRQYLNNIKKSNHDLY
LQYLKGEKKIRFNSKVITGSERSPIDVIAELNERGRQTGFIKLSGLNNSN
KSQGNTGTTFNSGWDRFELNILLDDLETRPSKSDYPRPRLLFTKDQYEYN
ITKRCERVFEIDKGNKTGYPVDDQIKKNYEDILDSYDGIKDQEVAERFDT
FTRGSKLKVGDLVYFHIDGDNKIDSLIPVRGKLDKALHPCTGLSDGLCPG
CHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERSLTLGVLESPRPAF
SIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQPERNVTTEVMDKGN
VFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGKPYGFGSVKIKIDS
LHTFKIIKRVPQSDIREYINKGYQKLIEWSLPQWHVIPHIDKLYKLLWVP
FLNDSKLEPDVRYPVLNYTYKKLGDKDNLPYKTRVKGLTTPWSPWNPFQV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8d97 Chain A Residue 1704 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d97 Craspase is a CRISPR RNA-guided, RNA-activated protease.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		C1013 C1401 C1412
Binding residue
(residue number reindexed from 1)		C965 C1340 C1351
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d97, PDBe:8d97, PDBj:8d97
PDBsum8d97
PubMed36007061
UniProtA0A0B0EGF3

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