Structure of PDB 8d2k Chain A Binding Site BS04

Receptor Information
>8d2k Chain A (length=1105) Species: 351607 (Acidothermus cellulolyticus 11B) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERS
GASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDA
WLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQ
PSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSLSN
ATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAER
IGRDPLDPSQLRASRACLEFQEYRIVAAVANLRIRDGSGSRPLSLEERNA
VIEALLAQTERSLTWSDIALEILKLPNESDLTSVPEEDGPSSLAYSQFAP
FDETSARIAEFIAKNRRKIPTFAQWWQEQDRTSRSDLVAALADNSIAGLL
VHLPDAELEALEGLALPSGRVAYSRLTLSGLTRVMRDDGVDVHNARKTCF
GVDDNWRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVEL
ARGASESRERQAEEEAARRAHRKANDRIRAELRASGLSDPSPADLVRARL
LELYDCHCMYCGAPISWENSELDHIVPRTDGGSNRHENLAITCGACNKEK
GRRPFASWAETSNRVQLRDVIDRVQKLKYSGNMYWTRDEFSRYKKSVVAR
LKRRTSDPEVIQSIESTGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAE
ARRWLDISIERLFSRVAIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKT
LADARSRRVSASTEEPQSPAYRQWKESCSGLGDLLISTAARDSIAVAAPL
RLRPTGALHEETLRAFSEHTVGAAWKGAELRRIVEPEVYAAFLALTDPGG
RFLKVSPSEDVLPADENRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGAA
YIASFHHARVFRWGSSHSPSFALLRVSLADLAVAGLLRDGVDVFTAELPP
WTPAWRYASIALVKAVESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSMF
LKYFPERHWVVTGFEDDKRINLKPAFLSAEQAEVLRTERSDRPDTLTEAG
EILAQFFPRCWRATVAKVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPWS
ADPWS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d2k Coupled catalytic states and the role of metal coordination in Cas9
Resolution2.43 Å
Binding residue
(original residue number in PDB)		D18 G20 E21 R22 S23 E54 R55 P675 I678 Q679 K743 R744 R747 H750 R919 F934 R954 T1041 G1042 F1043 E1044 E1059
Binding residue
(residue number reindexed from 1)		D12 G14 E15 R16 S17 E48 R49 P658 I661 Q662 K726 R727 R730 H733 R890 F905 R925 T1012 G1013 F1014 E1015 E1030
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8d2k, PDBe:8d2k, PDBj:8d2k
PDBsum8d2k
PubMed38348449
UniProtA0LWB3

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