Structure of PDB 8c49 Chain A Binding Site BS04

Receptor Information

>8c49 Chain A (length=274) Species: 1291540 (Methanomethylophilus alvi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VKYTDAQIQRLREYGNGTYEQKVFEDLASRDAAFSKEMSVASTDNEKKIK
GMIANPSRHGLTQLMNDIADALVAEGFIEVRTPIFISKDALARMTITEDK
PLFKQVFWIDEKRALRPMLAPNIFSVGRDLRDHTDGPVKIFEMGSCFRKE
SHSGMHLEEFTMLNLFDMGPRGDATEVLKNYISVVMKAAGLPDYDLVQEE
SDVFKETIDVEINGQEVCSAAVGPHYLDAAHDVHEPWSGAGFGLERLLTI
REKYSTVKKGGASISYLNGAKINL

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

8c49 Chain A Residue 313 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8c49 Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues.
Resolution	1.82 Å
Binding residue (original residue number in PDB)	D169 R173
Binding residue (residue number reindexed from 1)	D167 R171
Annotation score	1

Enzymatic activity

Enzyme Commision number

6.1.1.26: pyrrolysine--tRNA(Pyl) ligase.

Gene Ontology

	Molecular Function
GO:0004812	aminoacyl-tRNA ligase activity
GO:0043767	pyrrolysyl-tRNA synthetase activity
GO:0046872	metal ion binding

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Molecular Function

External links

PDB	RCSB:8c49, PDBe:8c49, PDBj:8c49
PDBsum	8c49
PubMed	37051694
UniProt	M9SC49

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