Structure of PDB 8asd Chain A Binding Site BS04

Receptor Information
>8asd Chain A (length=1826) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEI
KMLEQFLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEIN
RCEAIDKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDS
GFGSLMDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPEKDT
PKEAKITYRRFKPALSSSARQEFSLQGVEGKKWKRMAANQKKEKESHETL
SPFLDVEDIGDFLTFNNLLTDSRYGDESIQRAVSILLEKASAMQDTELTH
ALNDSFKRNLSSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWP
IYVIIKPTKSSSHIFYSLGIRKADVTRRLTGRVFSDTIDAGEWELTEFKS
LKTCKLTNLVNLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFL
ISLEDKSKTEEIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQV
YLLRKHLDCMVRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSW
YIGYYKNKEESTELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHE
FSRSFLRAACSSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKA
TSNFSKDWELYSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAV
LDDGCMRICLFKKNQHGGLREIYVMDANARLVQFGVETMARCVCELSPHE
TVANPRLKNSIIENHGLKSARSLGPGSININSSNDAKKWNQGHYTTKLAL
VLCWFMPAKFHRFIWAAISMFRRKKMMVDLRFLAHLSSKSESRSSDPFRE
AMTDAFHGNRDVSWMDKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKS
YFVSKLKEGYMGESISGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVA
NLLHSVKFLNPLFGIYSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIA
ASHQISETEALASRQEDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLL
GLCLHPLFGTFMGMLISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTT
DLGRKYAYYFNEIQGKTKGDEDYRALDATSGGTLSHSVMVYWGDRKKYQA
LLNRMGLPEDWVEQIDENPGVLYRRAANKKELLLKLAEKVHSPGVTSSLS
KGHVVPRVVAAGVYLLSRHCFRFSSSIHGRGSTQKASLIKLLMMSSISAM
KHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHLTGKFVVRERNIVRSRI
DLFQEPVDLRCKAEDLVSEVWFGLKRTKLGPRLLKEEWDKLRASFAWLST
DPSETLRDGPFLSHVQFRNFIAHVDAKSRSVRLLGAPVVTTISQVVRMNF
FPGFSLESISILKHVLFMVLNGPYTEEYKLEMIIEAFSTLVIPQPSEVIR
KSRTMTLCLLSNYLSSRGGSILDQIERAQSGTLGGFSKPQKTFVRPGGGV
GYKGKGVWTGVMEDTHVQILIDGDGTSNWLEEIRLSSDARLYDVIESIRR
LCDDLGINNRVASAYRGHCMVRLSGFKIKPASRTDGCPVRIMVKMRVRGD
ILNLSVTIQEGRVMNILSYRPRDTDI
Ligand information
Receptor-Ligand Complex Structure
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PDB8asd Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R318 Q426 G427 E429 K431 E443 K444 S446 H447 T449 H535 S562 H563 F565 S600 K605 K656 R695 E763 L764 N765 F1032 H1035 S1044 S1045 F1048 R1049
Binding residue
(residue number reindexed from 1)		R318 Q426 G427 E429 K431 E443 K444 S446 H447 T449 H535 S562 H563 F565 S600 K605 K656 R695 E763 L764 N765 F1032 H1035 S1044 S1045 F1048 R1049
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8asd, PDBe:8asd, PDBj:8asd
PDBsum8asd
PubMed36651274
UniProtU3GU88

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