Structure of PDB 8acg Chain A Binding Site BS04

Receptor Information

>8acg Chain A (length=468) Species: 287 (Pseudomonas aeruginosa)

SICKSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNRAAATPGYQ
ASVDYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQPVTYEWEKD
FTYLSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFPAGSIALIQ
RGTCNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGESYEGGIPV
IFATYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRGNPNNVVMV
GAHLDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFAWWGAAEAG
LVGSTHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDGSDFGLQGP
PGSAAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAFGGLFTGAE
GLKTEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHSDAMAFVTS
WLSLSTKVVDDEIAAAGQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8acg Chain A Residue 604

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8acg An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
• Resolution: 2.84 Å
• Binding residue (original residue number in PDB): P59 L62 D486
• Binding residue (residue number reindexed from 1): P16 L19 D443
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0015628 protein secretion by the type II secretion system
• GO:0043952 protein transport by the Sec complex

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:8acg, PDBe:8acg, PDBj:8acg
• PDBsum: 8acg
• PubMed: 37386135
• UniProt: Q9HZQ8|LAP_PSEAE Aminopeptidase (Gene Name=lap)