Structure of PDB 8a3w Chain A Binding Site BS04

Receptor Information
>8a3w Chain A (length=254) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKTVLSCRKGNGSVYQVHGHKRLGPAKLRILDYAERHGYMRGVVKSIEHE
AGRGAALARVEFRHPYKFRRVKELMVAPEGMFTGQSVFCGQKAPLAIGNV
LPLGQITEGCIVCNVEAKPGDRGTLARASGDYCIIISHNHETGRTRLKLP
SGQKKSVPSTSRAMIGIISGGGRIEKPVLKAGNSFYRFRGKRNCWPKVRG
VARNPVEHPHGGGNHQHIGHPSTVSRHSPPGQKVGLIAARRTGRIRGGKA
VKGA
Ligand information
>8a3w Chain 1 (length=1467) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
cgugguuggugcaggaguggcgaaauucaagaaagcaaacccguugcuga
auacaaucauggaguauugagccaaagaagguguuagcccauugagccau
aaaccugagcgccucaugaacuaagcgaguagcacuguuugggaaugcag
ugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaag
accgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaa
agagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuc
cauuucaacggccagaaccagcccuugcauuauccugugggaaauccggc
ggggugcaaugguguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauaugccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccggggaaacccagguggaggccuguagcgaugcugacgugca
aaucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccu
aguagcugguucacaucgaaguuucccucaggauagcuggugcuaguaga
aguauugugcgguaaagcacuuuaaaugugcaaacaaaccggccuuagcc
aacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuu
cgguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcg
ucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugcacc
ggccccgaaaauggaugacgcuuaagcccaauuagugauugcccauuauu
ccuuugguaagggcgagaaaguguagcccuuccgauguagauguggccug
gagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuag
ugcagaucuugguuggcguagcaaagaucuaacggagauauacucaacau
gcaacguuggauacuggagcggggaaggauuucgugccaacggcacucgu
acacgaguuguucggaaacugagcacaacguuauaucguuuuguuaggaa
agugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaa
aagaaauugcauguggg
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<.<<<<<......<<<...<<<<.......>>>>..
...<<....>>.....>>>.<<.......((.....>>)).....>>>>>
...>>>..>>>>>.>>>..............<<<<<<<........>>>>
>>>......<<<<<........>>>>>..>>>..................
..................<<....>>................<<<<....
>>>>..................................<<<..<<<<<<.
<<<<<......<<<<.<<<<.....<<<<<...<<<<<<<....>>..>>
>>>>>>>>.>>>>.>>>>......>>>>>>>>>>>..>>>.<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
>>>..>>>>...<<....>>..<<<<<...>>>>>...<<<<<...<<.<
<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>
>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<......
..>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>.
..>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<
<...<<<<<<....<<<..>>.>....>>>>>>.....<<<<<<<<.<<.
....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(
((......<..<<<<........<...........<<<<....<..>...
.>>>>...........))).>....>>>>.>.........>>>...>>>>
>>><<<<.<<<<<.............>>>>>>>>>....>>>>>..<.<<
<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>.
.>.....>>>>>>..............<<<<<<<................
....>>>>>>>....................<<<<<....<<.....>>.
.>>>>>....<<..........<<.<<<<<......>>>>..........
......<....>......>.>>..........<<<<.........>>...
.>>.>>...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
Resolution2.89 Å
Binding residue
(original residue number in PDB)		R9 S14 H19 H21 A182 F186 Y187 W196 V199 R204 N205 V207 E208
Binding residue
(residue number reindexed from 1)		R8 S13 H18 H20 A181 F185 Y186 W195 V198 R203 N204 V206 E207
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
PDBsum8a3w
PubMed
UniProtQ4FWX5

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