Structure of PDB 7x78 Chain A Binding Site BS04

Receptor Information

>7x78 Chain A (length=203) Species: 573 (Klebsiella pneumoniae)

MERNRLARQIIDTCLEMTRLGLNAGNVSVRYQGGMLITPTGIPYEKLTED
KIVFIDADGQHEQGKLPSSEWRFHQAAYQTRPDAQAVVHNHAVHCTAVSI
LNRPIPAIHYMIAAAGGNSIPCAPYATFGTRELSEHVAVALKHRKATLLQ
HHGLIACEASLEKALWLAHEVEVLAQLYLSTLAITDPVPVLDDEAIAIVL
EKF

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7x78 Chain A Residue 304

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7x78 Structural characterization of an L-fuculose-1-phosphate aldolase from Klebsiella pneumoniae.
• Resolution: 1.85 Å
• Binding residue (original residue number in PDB): E73 H92 H94 H155
• Binding residue (residue number reindexed from 1): E70 H89 H91 H152
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.1.2.17: L-fuculose-phosphate aldolase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008738 L-fuculose-phosphate aldolase activity
• GO:0016829 lyase activity
• GO:0016830 carbon-carbon lyase activity
• GO:0016832 aldehyde-lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005996 monosaccharide metabolic process
• GO:0006004 fucose metabolic process
• GO:0019317 fucose catabolic process
• GO:0019323 pentose catabolic process
• GO:0019568 arabinose catabolic process
• GO:0042355 L-fucose catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7x78, PDBe:7x78, PDBj:7x78
• PDBsum: 7x78
• PubMed: 35366538
• UniProt: A6TD81