Structure of PDB 7vg3 Chain A Binding Site BS04

Receptor Information
>7vg3 Chain A (length=860) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAGSKKRKELHGTTCANALSGTWGENIDGATFQAYKFDFCCNISGEVYSS
FSLLLESTLAEDVGKVEMDLYLVRKLVKASVSPCGQIRLSQEELVKAKYF
QQFFFNGMFGKLFVGSKSQGTKREFLLQTDTSSLWHPAFMFLLLPVETND
LASSATIDWSAINSCASIVEFLKKNNLIHFANASSDKNSLEELVVIAIHT
GRIYSIVEAVSDSSAMSPFEGYATYAEYFNKKYGIVLAHPNQPLMKLKQS
HHAHNLLVDFNEEMVRKRKPNIHAHLPPELLARIDVPRAVLKSIYLLPSV
MHRLESLMLASQLREEIDCSIDNFSISSTSILEAVTTLTCPESFSMERLE
LLGDSVLKYVASCHLFLKYPDKDEGQLSRQRQSIISNSNLHRLTTSRKLQ
GYIRNGAFEPRRWTAPGQFSLFPVPCKCGIDTREVPLDPKFFTENMTIKI
GKSCDMGHRWVVSKSVSDCAEALIGAYYVSGGLSASLHMMKWLGIDVDFD
PNLVVEAINRVSLRCYDELIELERKIQHEFSAKFLLKEAITHSSLRESYS
YERLEFLGDSVLDFLITRHLFNTYEQTGPGEMTDLRSACVNNENFAQVAV
KNNLHTHLQRCATVLETQINDYLMSFQKPGRSIPSIQGPKALGDVVESIA
GALLIDTRLDLDQVWRVFEPLLSPLVTPDKLQLPPYRELNELCDSLGYFF
RVKCSNDGVKAQATIQLQLDDVLLTGDGSEQTNKLALGKAASHLLTQLEK
RNISEIQSIVIPFIGPINMKKGGPRGTLHEFCKKHLWPMPTFDTSEEKSR
TPFEFIDGGEKRTSFSSFTSTITLRIPNREAVMYAGEARPDKKSSFDSAV
VELLYELERR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7vg3 Chain A Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7vg3 Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation.
Resolution3.73 Å
Binding residue
(original residue number in PDB)		C1093 C1119 H1123
Binding residue
(residue number reindexed from 1)		C428 C454 H458
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0006952 defense response
GO:0010267 ta-siRNA processing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0051214 RNAi-mediated antiviral immunity against RNA virus
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vg3, PDBe:7vg3, PDBj:7vg3
PDBsum7vg3
PubMed34648373
UniProtQ9LXW7|DCL3_ARATH Endoribonuclease Dicer homolog 3 (Gene Name=DCL3)

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