Structure of PDB 7vbc Chain A Binding Site BS04

Receptor Information
>7vbc Chain A (length=1477) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMPWRRLQGISFGMYSAEELKKLSVKSITNPRYLDSLGNPSANGLYDLAL
GPADSKEVCSTCVQDFSNCSGHLGHIELPLTVYNPLLFDKLYLLLRGSCL
NCHMLTCPRAVIHLLLCQLRVLEVGALQAVYELERILNRFSASEIREELE
QYTTEIVQNNLLGSQGAHVKNVCESKSKLIALFWKAHMNAKRCPHCKTGR
SVVRKEHNSKLTITFRGYLTPTSAREHLSALWKNEGFFLNYLFSRFNPSV
FFLDFLVVPPSRYRPVSRLGDQMFTNGQTVNLQAVMKDVVLIRKLLALMA
QEQSLIDKLYNIWIRLQSHVNIVFDSEMDKLMMDKYPGIRQILEKKEGLF
RKHMMGKRVDYAARSVICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQ
ELRQAVINGPNVHPGASMVINEDGSRTALSAVDMTQREAVAKQLLTQGTK
IVCRHVKNGDILLLNRQPTLHRPSIQAHRARILPEEKVLRLHYANCKAYN
ADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMV
SGASMTTRGCFFTREHYMELVYRGLTDKVGRVKLLSPSILKPFPLWTGKQ
VVSTLLINIIPEDHIPLNLSGKAKITGKAWVKETPRSVPGFNPDSMCESQ
VIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGKVLTCLARLFT
AYLQLYRGFTLGVEDILVKPKADVKRQRIIEESTHCGPQAVRAALNLPEA
ASYDEVRGKWQDAHLGKDQRDFNMIDLKFKEEVNHYSNEINKACMPFGLH
RQFPENSLQMMVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLP
CFEPYEFTPRAGGFVTGRFLTGIKPPEFFFHCMAGREGLVDTAVKTSRSG
YLQRCIIKHLEGLVVQYDLTVRDSDGSVVQFLYGEDGLDIPKTQFLQPKQ
FPFLASNYEVIMKSQHLHEVLSRADPKKALHHFRAIKKWQSKHPNTLLRR
GAFLSYSQKIQEAVKALKLESENRNGRSPGTQEMLRMWYELDEESRRKYQ
KKAAACPDPSLSVWRPDIYFASVSETFETKVDDYSQEWAAQTEKSYEKSE
LSLDRLRTLLQLKWQRSLCEPGEAVGLLAAQSIGEPSTQMMNVTLGIPRL
REILMVASANIKTPMMSVPVLNTKKALKRVKSLKKQLTRVCLGEVLQKID
VQEQVYQLRFQFLPHAYYQQEKCLRPEDILRFMETRFFKLLMESIKKKNN
KASEAMERRVQAVREIHPFIDDYQYDTEESLWCQVTVKLPLMKINFDMSS
LVVSLAHGAVIYATKGITRCLLNETTNNKNEKELVLNTEGINLPELFKYA
EVLDLRRLYSNDIHAIANTYGIEAALRVIEKEIKDVFAVYGIAVDPRHLS
LVADYMCFEGVYKPLNRFGIRSNSSPLQQMTFETSFQFLKQATMLGSHDE
LRSPSACLVVGKVVRGGTGLFELKQPL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7vbc Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7vbc Structure of the human RNA polymerase I elongation complex.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		C64 H77
Binding residue
(residue number reindexed from 1)		C59 H72
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:1904750 negative regulation of protein localization to nucleolus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7vbc, PDBe:7vbc, PDBj:7vbc
PDBsum7vbc
PubMed34671025
UniProtO95602|RPA1_HUMAN DNA-directed RNA polymerase I subunit RPA1 (Gene Name=POLR1A)

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