Structure of PDB 7uzr Chain A Binding Site BS04
Receptor Information
>7uzr Chain A (length=352) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKD
GNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYL
LEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLA
FFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIF
DK
Ligand information
>7uzr Chain J (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
7uzr
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
R222 K315 G316
Binding residue
(residue number reindexed from 1)
R74 K161 G162
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:7uzr
,
PDBe:7uzr
,
PDBj:7uzr
PDBsum
7uzr
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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