Structure of PDB 7uih Chain A Binding Site BS04

Receptor Information
>7uih Chain A (length=574) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGRHGVFLELSED
VEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYSARMNLASSFV
NGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLWDVDGGLT
QIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDFVLHNSNTM
RLGSIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAV
GSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAIL
AALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSK
FSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMV
RLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILG
KSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQQTHTTPVLLAHGER
AELATEEFLPVTPILEGFVILRKN
Ligand information
>7uih Chain F (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SSYSMHYIYPYSSYTYKYQWRGA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7uih Targeted degradation via direct 26S proteasome recruitment.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		D394 N396 L426 T427 D430 K431 Y434
Binding residue
(residue number reindexed from 1)		D117 N119 L149 T150 D153 K154 Y157
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:7uih, PDBe:7uih, PDBj:7uih
PDBsum7uih
PubMed36577875
UniProtQ13200|PSMD2_HUMAN 26S proteasome non-ATPase regulatory subunit 2 (Gene Name=PSMD2)

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